Angreal Research

Applied Computational Structural Biology Research & Consulting

Biological molecules – proteins, nucleic acids, membranes, etc., and the milieu they function in, are highly dynamic, and this dynamic nature is an intrinsic component the initiation, localization, development and maintenance of cell signaling pathways. These processes usually involve the complex interplay between multiple components and result in structural rearrangements that take place over microsecond to millisecond timescales. Recent advances in computing power make the analyses of these transitions possible and will provide insight into how events at the atomic scale can affect large-scale, “global” events in the cell. Furthermore, with the exciting advances in machine learning methods, we are poised to probe rare transitions that are normally inaccessible, even with long timescale molecular dynamics simulations.

At Angreal Research we use computational methods such at molecular dynamics simulations, enhanced sampling methods, machine learning methods, molecular modeling and protein design methods to understand biomolecular structure and function.

Contact us if you’d like to use these methods to understand your favorite biological system.

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